Liposomes, Niosomes, Microspheres, Nanoparticles
Start with the big picture
Liposomes are phospholipid bilayer vesicles with a hydrophilic core and a lipophilic bilayer, while niosomes use non-ionic surfactants and cholesterol. Both can carry hydrophilic and lipophilic drugs, but differ in stability, cost, and limitations. Microspheres are polymer matrices that can provide sustained or controlled release; their release may depend on degradation, diffusion, and erosion. Nanoparticles include matrix-forming nanospheres and core–shell nanocapsules, with polymeric, lipid, or inorganic materials. Their targeting approaches can include ligand attachment. Across these systems, the lesson distinguishes structures and applications while also considering challenges such as leakage, aggregation, burst release, and production or safety concerns.
What you'll learn
- Distinguish the structures and compositions of liposomes, niosomes, microspheres, and nanoparticles.
- Explain how liposomes and niosomes can encapsulate hydrophilic and lipophilic drugs.
- Differentiate microspheres from microcapsules and describe mechanisms governing microsphere drug release.
- Identify nanoparticle types, material classes, and ligand-based targeting approaches.
- Compare delivery applications and limitations across the four carrier systems.
Continue your study
Work through the complete notes and reinforce the topic with the study tools available in the full lesson.
