Pharmaceutics Semi-solid Dosage Forms

Types of Semi-solids (Creams, Ointments, Gels, Pastes)

Topic overview

Start with the big picture

Creams are emulsions that spread readily, while ointments are viscous, single-phase preparations that tend to be more occlusive. Gels use polymer networks to trap liquid and can provide a clear, cooling preparation; pastes are thicker ointments with a high solid content that helps them remain in place. These differences matter when matching a formulation to a site or skin condition. The lesson also connects base selection with washability, drug release, and preservative needs, and introduces quality checks such as rheology, pH, and in-vitro release. This preview outlines the key distinctions; the full lesson develops their formulation and practical implications.

Learning objectives

What you'll learn

  • Distinguish creams, ointments, gels, and pastes by composition and physical properties.
  • Relate ointment base types to occlusiveness, washability, and drug release.
  • Describe how gels and pastes differ in structure and application.
  • Match semi-solid types with the clinical uses described in the lesson.
  • Identify quality tests and preservative considerations for semi-solid formulations.
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