Tablet Formulation and Types of Tablets
Start with the big picture
A tablet may contain a diluent or filler, binder, disintegrant, lubricant, glidant, anti-adherent, and coating polymer alongside its API. These excipients serve distinct functions: binders support cohesiveness, disintegrants promote breakup in fluids, lubricants reduce friction during compression, and glidants improve powder flow. Their amounts matter; for example, excess binder can increase hardness and slow disintegration, while excess lubricant can delay dissolution. Wet granulation, dry granulation, and direct compression are manufacturing options selected in light of API characteristics. Quality assessment includes measures such as weight variation, hardness, friability, disintegration, dissolution, and content uniformity. Tablet types range from uncoated and coated forms to chewable, effervescent, buccal, sublingual, and orodispersible designs, each with distinguishing features.
What you'll learn
- Identify the core components used in tablet formulations.
- Describe how binders, disintegrants, lubricants, and glidants affect tablet properties.
- Relate API characteristics to the choice of tablet manufacturing route.
- Distinguish tablet types by their formulation, use, and performance characteristics.
- Recognize common tests used to assess tablet quality.
Continue your study
Work through the complete notes and reinforce the topic with the study tools available in the full lesson.
