Cardiovascular drugs (Digoxin, Reserpine)
Start with the big picture
Digoxin is a cardenolide glycoside obtained primarily from Digitalis lanata leaves. By inhibiting Na⁺/K⁺-ATPase, it increases intracellular calcium, strengthens cardiac contraction, and slows AV conduction. Its uses, renal elimination, monitoring, toxicity risks, and botanical authentication are key parts of the topic. Reserpine, an indole alkaloid from Rauwolfia serpentina roots, irreversibly blocks VMAT2 and depletes catecholamines and serotonin in the CNS and periphery. The lesson also considers its antihypertensive use, delayed onset, adverse effects, contraindications, interactions, and supportive management of toxicity. Comparing the two drugs highlights how plant source and mechanism relate to clinical effects and safety.
What you'll learn
- Identify the botanical sources and principal chemical features of digoxin and reserpine.
- Explain how digoxin affects intracellular calcium, cardiac contractility, and AV conduction.
- Summarize digoxin monitoring, toxicity features, risk factors, and management.
- Describe reserpine’s VMAT2 action, clinical use, adverse effects, and contraindications.
- Recognize authentication and isolation methods associated with these plant drugs.
Continue your study
Work through the complete notes and reinforce the topic with the study tools available in the full lesson.
