Topic overview

Start with the big picture

The lesson surveys several antidepressant groups and their characteristic pharmacology. Bupropion inhibits norepinephrine and dopamine reuptake and may support smoking cessation; mirtazapine’s receptor effects are associated with appetite, weight, and sedation changes. Trazodone and nefazodone share serotonergic features, while vilazodone and vortioxetine combine serotonin-related actions with distinct interaction and adverse-effect considerations. Amoxapine and maprotiline are covered as tetracyclic agents. The review also introduces intranasal esketamine and IV brexanolone, including their different indications, rapid effects, and monitoring concerns. Broader safety topics include boxed warnings, tapering, serotonin syndrome, special populations, organ considerations, CYP interactions, and overdose patterns.