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Pharmacology Antidepressant Agents

Clinical Applications and Adverse Effects

Topic overview

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The lesson surveys how antidepressant classes are used across depression, anxiety-related disorders, and selected pain or other conditions. It compares common agents, including SSRIs, SNRIs, TCAs, MAOIs, bupropion, mirtazapine, and trazodone, with newer serotonin-modulating and rapid-acting options. Key adverse effects range from gastrointestinal symptoms, sexual dysfunction, and sedation to blood-pressure changes and class-specific serious risks. The topic also introduces precautions that apply across antidepressant treatment, including the suicidality warning for people younger than 25 and the need for a washout period when switching between serotonergic drugs and MAOIs. These distinctions can help learners connect a medication’s potential role with its risks and safety considerations.

Learning objectives

What you'll learn

  • Identify common clinical uses of major antidepressant classes and selected agents.
  • Compare characteristic adverse effects across SSRIs, SNRIs, TCAs, and MAOIs.
  • Recognize selected uses and risks of atypical and rapid-acting antidepressants.
  • Describe universal antidepressant precautions, including suicidality and switching concerns.
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