Spasmolytics and Other Agents
Start with the big picture
Centrally acting spasmolytics modulate neurotransmission in the brain or spinal cord rather than blocking neuromuscular transmission. The lesson compares baclofen, tizanidine, diazepam, and cyclobenzaprine, linking their mechanisms and uses with important risks such as sedation, hypotension, dependence, or anticholinergic effects. It also surveys other centrally acting agents used mainly for acute musculoskeletal pain. Peripherally acting treatments include dantrolene, which blocks calcium release in skeletal muscle, and botulinum toxin A, which prevents acetylcholine release at injected sites. Additional sections introduce riluzole and cannabinoids, then connect mutant RyR1-related calcium release to malignant hyperthermia and its treatment with dantrolene. Safety, monitoring, agent selection, and common exam traps are also addressed.
What you'll learn
- Distinguish centrally acting from peripherally acting spasmolytics.
- Relate major agents’ mechanisms to their clinical uses and adverse effects.
- Describe dantrolene’s role in malignant hyperthermia management.
- Identify the mechanisms and uses of botulinum toxin A, riluzole, and cannabinoids.
Continue your study
Work through the complete notes and reinforce the topic with the study tools available in the full lesson.
