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CCBs support angina treatment by reducing vascular resistance and, in some cases, cardiac workload. Dihydropyridines are potent arterial vasodilators and can cause reflex tachycardia; non-dihydropyridines reduce SA and AV node conduction and contractility, making them useful when angina occurs with tachyarrhythmia. The lesson distinguishes their roles in stable, vasospastic, and microvascular angina, including their place in vasospastic angina and selected combination therapy. It also addresses adverse effects, contraindications, interactions, and differences in hemodynamic effects among nifedipine, diltiazem, and verapamil. Understanding these distinctions helps connect each drug’s pharmacology with its clinical use and monitoring needs.