Nicotinic Acid (Niacin)
Start with the big picture
Niacin is used as an adjunct in selected lipid disorders, including mixed hyperlipidemia, severe hypertriglyceridemia, and low HDL. Its effects on VLDL, triglycerides, LDL, and HDL are linked to actions in the liver and adipose tissue. Formulations differ, and the lesson outlines their dosing approaches alongside practical concerns such as flushing, metabolic effects, and hepatic toxicity. It also addresses contraindications, interactions with statins and other medicines, and monitoring of lipids, liver function, glucose, and uric acid. Cardiovascular outcome evidence is considered, including trials that did not show additional benefit when niacin was added to statin therapy. The preview provides an orientation to these topics; the full lesson develops their clinical connections and guidance.
What you'll learn
- Describe how niacin influences VLDL production, adipose lipolysis, and HDL.
- Summarize niacin’s lipid effects and clinical uses.
- Compare niacin formulations and their dosing approaches.
- Recognize key adverse effects, contraindications, and drug interactions.
- Identify monitoring considerations and cardiovascular outcome findings.
Continue your study
Work through the complete notes and reinforce the topic with the study tools available in the full lesson.
