Medical Microbiology Infection and Immunity

What is an infection? And modes of disease transmission.

Topic overview

Start with the big picture

This topic introduces infection as microbial invasion and multiplication accompanied by a host response, while distinguishing it from colonization without tissue damage. It outlines a chain of infection, from entry and adherence through multiplication, damage, and exit, and explains how reservoirs and portals shape transmission. Modes covered include direct and indirect contact, droplet and airborne spread, common vehicles, vectors, zoonoses, vertical transmission, and healthcare-associated sources. The lesson also introduces epidemiological concepts such as incubation periods and reproductive number, then connects transmission routes to infection-control precautions. Together, these ideas help organize how pathogens spread and where control measures can interrupt that spread.

Learning objectives

What you'll learn

  • Distinguish infection from colonization and symptomatic disease.
  • Describe the main steps in the chain of infection.
  • Identify reservoirs, portals, and major modes of transmission.
  • Explain how incubation and reproductive number relate to transmission.
  • Relate transmission routes to infection-control precautions.
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