Sterility and asepsis
The bacterial growth cycle
Growth media and methods
Environmental factors influencing microbial growth
Hazard categories of microorganisms
Sources and preservation of microorganisms
Bacterial morphology
Teichoic acids
Cytoplasmic membrane
Inclusion bodies (storage granules)
The bacterial chromosome
Ribosomes
Fimbriae (pili)
Capsules
Bacterial endospores
The cell wall
Lipopolysaccharide (endotoxin)
Plasmids
Flagella
Definitions and main characteristics
Pathogenic fungi
Commercially important fungi
Cultivation of protozoa
Protozoal infections
The characteristics and transmission of some of the major protozoal infections
The transmission, prophylaxis and treatment of malaria
The pharmaceutical importance of viruses
Virus structure and replication
Viral infections
Virus survival outside the body and susceptibility to disinfection
Nonliving infectious particles
Chlamydiae
Rickettsiae
Mycoplasmas
What is an infection? And modes of disease transmission.
Immune response to infection
Vaccination and vaccines
Mechanisms of antibiotic action
Factors to consider in selecting an antibiotic
Antibiotic combinations
Using antibiotics for prophylaxis
The frequency of use of the major groups of antibiotics
Cephalosporins
Other b-lactam antibiotics
Tetracyclines
Quinolones
Aminoglycosides
Other antibiotics
Penicillins
Macrolides
Sulphonamides and trimethoprim
Glycopeptides
Common fungal infections
Agents used to treat fungal infections
Treatment of common fungal infections
Viral infections
Targets for antiviral agents
Antiviral agents active against the herpes group of viruses
Inorganic pyrophosphate mimics
Influenza
Anti HIV drugs and Highly Active Antiretroviral Therapy HAART
Viral hepatitis
Respiratory syncytial virus
Innate (intrinsic) resistance
Measurement of resistance
Resistance mechanisms at the cellular level
b-lactamases and extended-spectrum b-lactamases (ESBLs)
Origins of antibiotic resistance
Antibiotics: a resource to be protected.
Availability of antibiotics to the public
antibiotic stewardship programmes and their aims
Defination, traditional and automated bioburden determinations
Detection of objectionable organisms
Identification of microorganisms
classes of biocidal agents
Measurement of antibacterial activity
Preservative efficacy testing
Disinfectant testing
Ch. 17: The manufacture of medicines: product contamination and preservation
5Topics
