Medical Microbiology Antifungal agents

Treatment of common fungal infections

Topic overview

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The lesson organizes antifungal treatment by infection type. It outlines echinocandin initiation and possible fluconazole step-down for candidemia, alongside options for oral and vulvovaginal candidiasis. For invasive infections, it contrasts preferred or alternative therapies for aspergillosis and mucormycosis with induction and follow-on treatment for cryptococcal meningitis. It also covers treatment patterns for histoplasmosis, blastomycosis, coccidioidomycosis, and sporotrichosis, noting that disease severity can affect the approach. Superficial infections are grouped by site: tinea, nail fungus, and tinea versicolor. Across these topics, the preview highlights that azole-related CYP450 inhibition may require attention to levels or toxicity of interacting medicines.

Learning objectives

What you'll learn

  • Compare treatment approaches for candidemia and mucosal candidiasis.
  • Identify therapies used for major invasive fungal infections.
  • Distinguish treatment patterns for endemic mycoses by disease severity.
  • Describe options for dermatophyte, nail, and tinea versicolor infections.
  • Recognize the interaction concern associated with azole CYP450 inhibition.
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